Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
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چکیده
منابع مشابه
Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer.
In the United States each year, almost 13,000 deaths are attributable to bladder cancer, with the majority of these deaths related to higher stage, muscle-invasive solid tumors. Epigenetic silencing of the secreted frizzled receptor proteins (SFRP), antagonists of the WNT pathway, leads to constitutive WNT signaling, altering cell morphology and motility. Identifying alterations in this pathway...
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Epigenetic DNA methylations plays an important role in oral carcinogenesis. The soluble frizzled receptor protein (SFRP) family together with WIF-1 and DKK-3 encodes antagonists of the WNT pathway. Silencing of these genes leads to constitutive WNT signalling. Because aberrant expression of beta-catenin might be associated with the epigenetic inactivation of WNT inhibitors, we analyzed, in a co...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2004
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1330